In order to fill a Combitip advanced completely, more liquid is required than indicated by its maximum value. Total
filling volumes were measured to determine the actual filling volumes required for the Combitips advanced. These
data led to recommendations regarding the volumes which should be provided to fill each Combitip advanced. In
addition, positive displacement tips from two competitors were tested alongside the Combitips advanced, and the
ratios between filling volume and maximum volume were analyzed.